GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP Research Proposal - 1

GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP LEVEL in the diagnosis of Heart failure - Research Proposal Example To help establish the outcomes, the study will be embedded on extracting DNA samples from 80 patients undergoing elective cardiac catheterization and analyzing with exclusion done on patients with elevated troponin. This will be driven by a detailed data collection including laboratory, standard demographic, catheterization and echocardiographic data. The Genotype will be evaluated at 19 loci on five BNP’s pathway relevant genes (Knowles, Erickson, Guy et al, 2003). To access the incremental influence of the genetic variants, the researcher will employ the Multivariate linear regression of logBNP model adjusted for clinical variables. The proposal will thus try to help properly incorporate the use of NPs to improve the levels of accuracy with respect to decisions made in an emergency setting to curb the missed incidence of diagnostic failures for HF. This will be measured by reduced cases of fatigue, dyspnea, and fluid retention that are all predisposing factors to HF based on cardiac dysfunction hence presenting difficulties in diagnosing HF. The missed incidence are hence strongly correlate to highly significant mortality increases, presenting the need for designing effective diagnostic tools with higher degrees of specification and sensitivity that if employed, can help weed out the increased cases of HF missed diagnose s and particularly, in the busy Heart failure is characterized by its typical but non-specific symptoms like fatigue, dyspnea and fluid retention caused by dysfunction of cardiac which present daunting challenges for diagnosis of HF culminating into increased missed incidence hence higher mortality rates. For this reason, the topic has captured the attention of various researchers to help design effective mechanism and approaches that can be used during diagnosis to detect this catastrophic cardiovascular disease quickly and accurately. For instance, to gauge the potentiality of NPs in augmenting the clinical judgment and/or standard

Logical fallacies in an editorial (editorial rebuttel) Essay

Logical fallacies in an editorial (editorial rebuttel) - Essay Example Since the authors name is not disclosed, the views expressed therein can be attributed to the Editorial Board of USA Today. In the immediate aftermath of the catastrophic oil spill in the Gulf of Mexico, the Obama Adminstration issued a moratorium banning all drilling activity in the region for the next six months. This meant that all 33 oil rigs in the Gulf will remain idle, along with tens of thousands of oil-rig workers. The moratorium elicited mixed reactions from different sections of society and body politic. The republicans accuse President Obama of pandering to the insecurities and fears of the masses, whereas public opinion is fairly supportive of this decision. The editorials central argument is that the moratorium is too arbitrary a measure; and that the Obama Adminstration could have drawn up more specific set of criteria for the reopening of rigs. The author goes one step ahead and enlists three specific criterions for the eventual reopening of rigs. These are: â€Å"Is it safe to drill?, Is there a credible plan for plugging a blowout?, and Is the industry capable of cleaning up a catastrophic spill?†. He further explains the rationale behind these questions. To this extent there seems to be no editorial bias one way or the other. Major newspapers in the United States are classified as either liberal or conservative; and it appears that the author takes up neither position in the article. Hence it is easy to come to the conclusion that the editorial is not ideologically slanted, and that it espouses neither the right-wing nor the left-wing perspective. But a closer examination reveals more fundamental deficiencies. Beneath the veneer of being objective and critical, one could detect the soft stance toward major oil corporations. Given the sheer scale of the oil-spill catastrophe, one would expect a